2018 HER2 Focused Update - MBPHER207W.2020
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This Multidisciplinary Breast Pathology (MBP) activity is intended for pathologists participating in the MBP program as well as pathologists looking for timely information on the 2018 HER2 Focused Update.

Credit Type: CME
Duration: 1 hour 15 minutes
Launch Date: July 1, 2020
Expiration Date: June 30, 2023 12:00 AM (ET)
Pricing: Junior Member Fee: $10.00
MOC Category: Medical Knowledge, Patient Care

In 2018, the American Society of Clinical Oncology and the College of American Pathologists developed a focused update on human epidermal growth factor receptor 2 (HER2) testing in breast cancer. The focused update endorses the 2013 HER2 testing guidelines while addressing outstanding questions related to HER2 testing. It focuses on specific clinical topics that have been raised by the clinical community and in the literature since the publication of the 2013 guidelines. This activity addresses each of the clinical questions and includes case studies that illustrate the practical application of what has been proposed in this update.

As a result of participating in this activity, you should be able to:

  1. Describe the purpose of the 2018 HER2 Focused Update.
  2. State the most appropriate definition for IHC2+ (IHC equivocal).
  3. Clarify if HER2 testing must be repeated on a surgical specimen if initially negative test on core biopsy.
  4. Explain if invasive cancers with a HER2/chromosome enumeration probe 17 (CEP17) ratio of ≥2 but an average HER2 copy number of <4.0 signals per cell should be considered ISH positive.
  5. Explain if invasive cancers with an average HER2 copy number of ≥6.0 signals per cell but a HER2/CEP17 ratio of <2.0 should be considered ISH positive.
  6. Explain the appropriate diagnostic workup for invasive cancers with an average HER2 copy number ≥4.0 but <6.0 signals per cell and a HER2/CEP17 ratio <2.0 and initially deemed to have an equivocal HER2 ISH test result.

CME Information
Accreditation: The College of American Pathologists (CAP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CME Category 1: The College of American Pathologists designates this internet enduring material educational activity for a maximum of 1.25 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Completion Requirements
You must answer the assessment questions and complete the evaluation to claim credit and print your certificate.

Payment Information
To pay with a check, print a copy of this page and send it with your check to the address below. You will be notified when your payment has been processed and you have been registered into the activity.

College of American Pathologists
CAP Learning
325 Waukegan Road
Northfield, IL 60093-2750

Refund Policy
Refunds will be handled on an exception basis. Please submit your request to the CAP in writing via email at education@cap.org or fax at 847-832-8006.

Technical Requirements
Pop-up blockers must be turned off.

CAP Learning has recognized that some Veteran’s Administration, US Government, and military participants may have difficulty accessing the online assessment portion of this activity. If you experience difficulty or have any questions, please contact a representative of the CAP Learning Division at 800-323-4040 option 1 or education@cap.org.

This activity and evaluation are available July 1, 2020, and expire June 30, 2023, at 12:00 AM (ET). You must claim credit by this date and time.

CC: MBPHER207W.2020

Non-Member Price:     
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2018 HER2 Focused Update