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B-ALL MINIMAL RESIDUAL DISEASE - BALL
BALL
Analytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

Analyte Challenges per Shipment Number of Shipments
B-ALL minimal residual disease 3 Two shipments per year

Survey BALL is intended for laboratories that currently or will begin to perform minimal residual disease (MRD) testing (rare event analysis) for B lymphoblastic leukemia/lymphoma. The cases presented will be based on Children's Oncology Group (COG) approved B-ALL MRD method.

Minimum Requirements

  • For ungated list mode files, each challenge will include 2-3 "virtual tubes" performed by a 6-color method. The participant will download the files from a CAP website and analyze the data on a MAC or PC using standard software, including FlowJo, FACSDiva, Kaluza, Woodlist, etc. The files will be large as each tube will have collected hundreds of thousands of events. Boolean gating will be necessary to see if there is an atypical population.
  • Demo list mode files are available for download to determine software compatibility prior to enrollment. Go to fileshare.cap.org (username: demo-b-all-mrd; password: ProductTest1).

Program Information

  • One 1.1-mL specimen containing a cell line/whole blood mixture simulating B lymphoblastic leukemia/lymphoma minimal residual disease with clinical history
  • Two cases with ungated list mode files that allow users to examine gating strategies and interpret antibody staining patterns; files are in standard format (see Minimum Requirements)

Shipping Schedule

  • Shipment A: January 13
  • Shipment B: July 15






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