Help Please log in to determine if you are eligible to purchase PT Programs. IGHV MUTATION ANALYSIS - IGHV  Analytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS). Analyte/Procedure Challenges per Shipment Number of Shipments IGHV 3 Two shipments per year Additional Information Sequence analysis of the clonal immunoglobulin heavy chain V gene (IGHV) to determine somatic hypermutation (SHM) status. Any sequencing method may be used. Report V-gene allele, percent similarity and mutation status (SHM). Program Information Three 20-µg DNA specimens (200 ng/µL) Shipping Schedule Shipment A: March 31 Shipment B: November 3 Guest Log in/Register