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NGS SOLID TUMOR - NGSST
NGSST
Analytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

Procedure Challenges per Shipment Number of Shipments
Next‑generation sequencing 3 Two shipments per year

Additional Information

  • This is a methods‑based proficiency challenge for laboratories performing targeted next‑generation sequencing of cancer genes or mutation hotspots in solid tumors. Laboratories will be asked to identify somatic single nucleotide variants and small insertions or deletions in the following genes: AKT1, ALK, APC, ATM, BRAF, CDH1, CTNNB1, EGFR, ERBB2, FBXW7, FGFR2, GNAQ, GNAS, HRAS, IDH1, KIT, KRAS, MET, NRAS, PDGFRA, PIK3CA, PTEN, SMAD4, SMARCB1, SMO, SRC, STK11, TP53.
  • This Survey includes variants present with a variant allele fraction (VAF) potentially as low as 5%.

Program Information

  • Three 1.0‑μg DNA (50 ng/μL) specimens

Shipping Schedule

  • Shipment A: March 26
  • Shipment B: October 1






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