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Proficiency Testing/EQA / 2026 Surveys / Genetics and Molecular Pathology /
Next-Generation Sequencing

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NGS SOLID TUMOR BIOINFORMATICS - NGSB1
NGSB1
Analytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

Analyte/Procedure Challenges per Shipment Number of Activities
Illumina TruSight Tumor 15 Panel 1 Two online activities per year
Illumina TruSight Tumor 170 Panel 1
Illumina TruSight Oncology 500 Panel 1
Thermo Fisher Ion AmpliSeq Cancer Hotspot Panel v2 1
Thermo Fisher Oncomine Comprehensive Assay v3 1
Thermo Fisher Oncomine Focus Cancer Panel 1

Additional Information

  • This in silico bioinformatics program is designed to complement and augment somatic variant wet bench NGS proficiency testing programs by testing a greater diversity of variants at a greater range of variant allele fractions as follows: (VAF).
  • This program includes variants present with a VAF potentially as low as 5%.
  • For platform-agnostic solid tumor bioinformatic proficiency testing challenges, refer to the NGSB4 program

Program Information

  • Sequencing files containing somatic variants to be downloaded and incorporated into your laboratory bioinformatics pipeline for analysis and reporting; file sizes range from 100MB to 1GB
  • The BAM and/or FASTQ files are platform‑specific and cannot be used with other instruments/software.
  • Your CAP shipping contact will be notified via email when the activity is available

Shipping Schedule

  • Shipment A: February 2
  • Shipment B: August 10






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