Description
This activity will focus on important aspects in diagnosing brain tumors in the era of molecular diagnosis, presented by a neurosurgeon introducing cases and a pathologist identifying crucial diagnostic aspects. They provide guidance on key elements of the final pathology report that are critical when making treatment decisions for patients with infiltrating gliomas. Also discussed are identifying features that aid in distinguishing infiltrating gliomas from other types of glial tumors and cortical dysplasia. You will learn to distinguish key features using an algorithmic approach to their identification and see real-life scenarios during a discussion incorporating the neuropathology, neurosurgery, and neuro-oncology perspectives.

This activity was originally presented at CAP24 as Brain Tumor Diagnosis in the Molecular Era: What the Neurosurgeon and Neuro-Oncologist Need to Know.

Objectives
After completing this activity, you should be able to:

1. Identify key MRI features that are helpful to the pathologist in the preoperative differential diagnosis of infiltrating gliomas.
2. Recognize key histologic findings for the diagnosis of glioblastoma IDH-wildtype; astrocytoma IDH-mutant; and oligodendroglioma-IDH-mutant and 1p/19q codeleted.
3. Describe the important molecular alterations that influence diagnosis and grading of infiltrating gliomas and when molecular testing is required.
4. Explain important aspects of evaluating and reporting cases in which surgery is performed to distinguish recurrent tumor (true progression) versus radiation necrosis (pseudoprogression).

CME Information
Accreditation: The College of American Pathologists (CAP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CME Category 1: The College of American Pathologists designates this internet enduring material educational activity for a maximum of 1.25 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Payment Information
To pay with a check, print a copy of this page and send it with your check to the address below. You will be notified when your payment has been processed and you have been registered into the activity.

College of American Pathologists
Education Division
325 Waukegan Road
Northfield, IL 60093-2750

Refund Policy
Refunds will be handled on an exception basis. Please submit your request to the CAP in writing via email at education@cap.org or fax at 847-832-8006.

Technical Requirements
Pop-up blockers must be turned off.

CAP Learning has recognized that some Veteran’s Administration, US Government, and military participants may have difficulty accessing the online activity. If you experience difficulty or have any questions, please contact a representative of the Customer Contact Center at 800-323-4040 option 1 or education@cap.org.

Availability
This activity and evaluation are available March 17, 2025, and expire March 16, 2028, at 11:59 PM (CT). Upon completion of the activity your credit will be awarded. Your certificate may be downloaded from your Transcript.

CC: NPBRAINTM03W.2025