Proficiency Testing/EQA / 2024 Surveys / Genetics and Molecular Pathology / Biochemical and Molecular Genetics Help Please log in to determine if you are eligible to purchase PT Programs. MOLECULAR GENETICS SERIES - MGL1 Analytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS). Disease/Gene Challenges per Shipment Number of Shipments Factor V Leiden (F5 gene) 3 Two shipments per year Fragile X (FMR1 gene) 3 Hemochromatosis (HFE gene) 3 Methylenetetrahydrofolate reductase (MTHFR gene) c.665C>T (677C>T) and c.1286A>C (1298A>C) 3 Plasminogen activator inhibitor (PAI)‑1 (SERPINE1 gene) 3 Prader‑Willi/Angelman syndrome 3 Prothrombin (F2 gene) 3 Additional Information The Prader-Willi/Angelman syndrome program is designed for laboratories using methylation techniques for analysis. The Spinal Muscular Atrophy program includes SMN1 and SMN2 gene analysis and copy number analysis. Program Information Three 50.0‑μg extracted DNA specimens per disease/gene Shipping Schedule Shipment A: March 11 Shipment B: August 5 Guest Log in/Register