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Transfusion medicine involves many hot-seat decisions that span a wide patient spectrum—from surgery and hematology/oncology to obstetrics and neonatology. Transfusion Medicine in the Hot Seat is a useful text for pathology trainees and an educational resource for pathologists who cover transfusion medicine. The text is divided into three sections: antibodies, blood components, and complications. Each section presents numerous short cases that illustrate real-world transfusion scenarios, with 26 cases total. The short-case format makes the information easily accessible and can serve as the basis for a transfusion medicine curriculum in clinical pathology.